Our new paper on bioactive glasses published in Biomaterials Science
Our new paper “Cu, Zn doped borate bioactive glasses: Antibacterial efficacy and dose-dependent in vitromodulation of murine dendritic cells”, . This is the result of a research collaboration with Dr. Elisabeth Zinser, Department of Immune Modulation, University Hospital Erlangen (Head: Prof. A. Steinkasserer) in the framework of the doctoral thesis of Ms Katharina Schuhladen, collaborating also with Dr. Jochen Schmidt (Institute of Particle Technology, FAU). The paper focuses on the influence that bioactive glasses (BGs) could have on the immune system. In particular, we investigated the interaction between undoped and Cu and/or Zn-containing borate BGs with dendritic cells, which are known to be the most potent antigen-presenting cells of the immune system. Our results indicate that there is a dose-depending and composition depending effect of the ionic dissolution products of BGs on the modulation and regulation of immune responses of dendritic cells. The study also includes results on the antibacterial properties of the investigated glasses.
[1] K. Schuhladen, et al., Cu, Zn doped borate bioactive glasses: Antibacterial efficacy and dose-dependent in vitromodulation of murine dendritic cells, Biomater. Sci. (2020) in press.
