Maryam Alizadeh

Visiting PhD Student (Sharif University of Technology, Iran)

Bioactive hydrogels for regeneration of osteoporotic bone fractures

 

Supervisor in Iran: Prof. M.J Abdekhodaie

Supervisor in Erlangen: Prof. Aldo R. Boccaccini

Osteoporosis, also known as the silent epidemic, affects over 200 million individuals worldwide and causes over 9 million fractures annually [1].  The impaired bone formation and accelerated bone resorption result in the failure of conventional clinical treatments for osteoporotic fractures. The development of bioactive bone substitutes is a promising approach to overcome this clinical challenge [2]. In the present study, a bioactive in-situ forming hydrogel will be fabricated by incorporation of drug-loaded mesoporous bioactive glass nanoparticles into the hydrogel matrix for the treatment of osteoporotic bone fractures.

[1]    M. K. Skjødt and B. Abrahamsen, “New insights in the pathophysiology, epidemiology, and response to treatment of osteoporotic vertebral fractures,” J. Clin. Endocrinol. & Metab., p. dgad256, 2023.

[2]     G. L. Koons, M. Diba, and A. G. Mikos, “Materials design for bone-tissue engineering,” Nat. Rev. Mater., vol. 5, no. 8, pp. 584–603, 2020.