Assoc. Prof. Dr. Vida Khalili

Visiting Researcher (University of Bonab, Iran)

An Intelligent Architecture of Microstructure to Modulate Biodegradation in Mg-based Temporary Orthopedic Implants

 

Hosts:

Prof. Dr.-Ing. Aldo R. Boccaccini, Friedrich Alexander University of Erlangen-Nuremberg, Erlangen

Prof. Dr.-Ing. Gunther Eggler, Ruhr University Bochum, Bochum

Mg alloys have become promising candidates for temporary implants, because they combine strength and lightweight with biodegradability, which avoids additional surgery for implant removal. The major drawback of Mg alloys is their fast degradation in biological media. They dissolve and the associated production of H2 can have a detrimental effect on pH-dependent physiological processes. To improve biomedical performance, it is important to control the degradation rate, to ensure that the implant maintains its mechanical integrity until the bone heals. This requires strict control of alloy composition and microstructural evolution during alloy processing. Moreover, optimum surface morphologies need to be established. The main challenge of this project is to design an intelligent architecture of microstructure and surface modification of Mg-alloy, which is required to modulate the biodegradability rate of temporary orthopedic implants. This project is being carried on in the framework of the “Experienced Researchers Georg Forster Research Fellowship of the Alexander von Humboldt Fellowship”.

[1] Khalili V., Sengstock C., Kalchev Y., Pfetzing-Micklich J., Frenzel J. (2022): Exploring MgO/HA ceramic nano-composites for biodegradable implants: Exploring biological properties and micromechanics. In: Surface and Coatings Technology, Vol. 445, 128730. DOI: https://doi.org/10.1016/j.surfcoat.2022.128730

[2] Khalili, V.*, Moslemi, S., Ruttert, B., Frenzel, J., Theisen, W., Eggeler, G. (2021): Surface metal matrix nano-composite of magnesium/hydroxyapatite produced by stir-centrifugal casting. In: Surface and Coatings Technology, Vol. 406, 126654. DOI: https://doi.org/10.1016/j.surfcoat.2020.126654

[3] Khalili, V.*, Frenzel, J., Eggeler, G. (2021): Degradation behavior of MgO/HA surfaced ceramic nano-composite in the simulated body fluid and its use as a potential bone implant. In: Materials Chemistry and Physics, Vol. 258, 123965. DOI: https://doi.org/10.1016/j.matchemphys.2020.123965