Carolin Messerschmidt

Bachelor student

Fabrication of composite coatings based on chitosan and bioactive glasses with phytotherapeutic drugs by electrophoretic deposition

 

Supervisors: Muhammad Asim Akhtar, Prof. Dr.-Ing. habil. Aldo R. Boccaccini

Despite the widespread use of metallic implants, they often fail due to insufficient bone bonding or the development of bacterial infections [1]. To overcome these problems, chitosan, bioactive glass particles and a phytotherapeutic drug will be used for developing bioactive and antibacterial coatings in this project. Electrophoretic deposition (EPD) will be used for obtaining coatings on stainless steel [2]. The aim of the project is to optimize the coating process, the characterization of the coating properties, including degradation in simulated body fluid and to study the release kinetics of the incorporated drugs.

[1] Akhtar MA, Ilyas K, Dlouhý I, Siska F, Boccaccini AR. Electrophoretic Deposition of Copper(II)–Chitosan Complexes for Antibacterial Coatings. International Journal of Molecular Sciences. 2020; 21(7):2637.

[2] Pishbin F, Mouriño V, Flor S, Kreppel S, Salih V, Ryan MP, Boccaccini AR. Electrophoretic Deposition of Gentamicin-Loaded Bioactive Glass/Chitosan Composite Coatings for Orthopaedic Implants. ACS Applied Materials & Interfaces. 2014; 6 (11), 8796-8806.