Dr. Michał Dziadek

Visiting researcher (Jagiellonian University, Department of Inorganic Chemistry, and AGH University of Science and Technology, Department of Glass Technology and Amorphous Coatings, Krakow, Poland)

Hypoxia-mimicking bioactive materials with high osteogenic and angiogenic potential

 

Collaborators: Zoya Hadzhieva, Prof. Aldo R. Boccaccini

Developing multifunctional biomaterials that can simultaneously promote bone formation and stimulate the formation of new blood vessels is one of the priority challenges of bone tissue engineering.
In this project, biomaterials with high osteogenic potential, namely silicate bioactive glasses (BGs) are used as carriers for hypoxia-mimicking transition metals (TMs – Cu, Co) – inorganic proangiogenic agents. The primary goal of this project is to investigate the effect of concentrations of TMs, glass CaO/SiO2 molar ratios and glass preparation methods (melt-quenching, sol-gel, sol-gel-EISA) on glass structure, valance state and oxygen coordination number of TMs, as well as textural properties of obtained glasses. This will allow us to answer the important question: how these glass characteristics affect the profiles of therapeutic element dissolution, glass bioactivity, and thus angiogenic and osteogenic activity.
The project is funded by the National Science Centre, Poland, (https://www.ncn.gov.pl/en) grant no. 2019/32/C/ST5/00386 in the frame of SONATINA program.