Franziska Noß

Bachelor student

Programmable Electrofabrication of multifunctional bilayer films for guided bone regeneration

 

Supervisors: Muhammad Asim Akhtar, Prof. Aldo R. Boccaccini

Asymmetric polymer films attract increasing attention for biomedical applications, due to their biodegradable, bioactive and antibacterial functions.
The natural biopolymer chitosan and mesoporous bioactive glass nanoparticles can be used to fabricate multifunctional bilayer films for guided bone regeneration (GBR) [1]. Soluble salts induce pore generation of the porous layer. In this study a stepwise electrophoretic deposition (EPD) method under programmable salt environment will be used at room temperature following a similar approach reported in literature [2]. Additionally, the influence of the different process parameters will be characterized and investigated in order to enable a flexible and adaptable application.

[1] M. A. Akhtar et al., Electrophoretic deposition of ferulic acid loaded bioactive glass/chitosan as antibacterial and bioactive composite coatings, Surface and Coatings Technology, 2021, 405, 126657.

[2] M. Lei, et al., Programmable Electrofabrication of Porous Janus Films with Tunable Janus Balance for Anisotropic Cell Guidance and Tissue Regeneration, Advanced Functional Materials, 2019, 29(18), 1900065.