Ibon Otaegui Chamorro

Visiting student (Mondragon University, Spain)

Development of 3D Printed Alginate (ADA)/ Gelatin (GEL) Hydrogels Enriched with Mesoporous Bioglass Nanoparticles (MBGN) and Phytochemicals for Soft Tissue Engineering

 

Supervisors: Memoona Akhtar, Prof. Aldo R. Boccaccini

3D bioprinting holds significant promise for various applications, including tissue engineering, regenerative medicine, drug discovery, and disease modeling to create customized, patient-specific tissues and organs for transplantation, study disease mechanisms, and to develop new therapeutic strategies [1]. This study will investigate the development of Alginate Dialdehyde-Gelatin (ADA-GEL) hydrogel scaffolds via Schiff base formation [2] enriched with Mesoporous Bioglass Nanoparticles (MBGN) and phytochemicals using advanced 3D printing techniques, and then it will evaluate the 3D printed structures in terms of morphological, compositional, mechanical, and biological analysis. Another primary focus of this study is the development of 3D printed scaffolds as well as investigation of the release kinetics, and degradation behavior of the fabricated scaffolds with a specific emphasis on their impact on cellular responses. The wound-healing potential of these innovative scaffolds will be also considered.

[1]        S. S. Athukoralalage, R. Balu, N. K. Dutta, and N. R. Choudhury, “3D bioprinted nanocellulose-based hydrogels for tissue engineering applications: A brief review,” Polymers (Basel)., vol. 11, no. 5, pp. 1–13, 2019, doi: 10.3390/polym11050898.

[2]        F. F. Cai, S. Heid, and A. R. Boccaccini, “Potential of Laponite® incorporated oxidized alginate–gelatin (ADA-GEL) composite hydrogels for extrusion-based 3D printing,” J. Biomed. Mater. Res. – Part B Appl. Biomater., vol. 109, no. 8, pp. 1090–1104, 2021, doi: 10.1002/jbm.b.34771.