Jan Novak

Bachelor student

Electrofabrication of chitosan films/ porous patches for biomedical applications

 

Supervisor:  Muhammad Asim Akhtar and Prof. Aldo R. Boccaccini

Chitosan is a well-known natural biopolymer. This polysaccharide is a promising candidate for different biomedical applications due to its biodegradability, intrinsic antibacterial and cytocompatible nature [1]. Electrophoretic deposition (EPD) is a versatile and widely used process that can be carried out at room temperature [2]. In this study the EPD process will be used to manufacture chitosan based free-standing porous patches modified with therapeutic ions and phytotherapeutic agents. A recent study found increased antibacterial activity and improved mechanical properties of copper(II)-chitosan complex based coatings obtained by EPD [3].  The characterization of the fabricated 3D shapes will take part in this study.

[1] J. M. Vaz, et al., Antibacterial Coatings Based on Chitosan for Pharmaceutical and Biomedical Applications, Current Pharmaceutical Design, 2018, 24, 866-885

[2] E. Avcu, et al., Electrophoretic deposition of chitosan-based composite coatings for biomedical applications:  A review. Prog. Mater. Sci.2019,103,69–108.

[3] M. A. Akhtar et al., Electrophoretic Deposition of Copper(II)–Chitosan Complexes for Antibacterial Coatings, Int. J. Mol. Sci. 2020, 21, 2637.