Jana Reh

Masterstudent

Incorporation of mesoporous bioactive glass particles doped with a phytotherapeutics agent into alginate-based hydrogels for 3D bioprinting

 

Supervisors: Faina Bider, Prof. Aldo R. Boccaccini

Tissue Engineering (TE) represents a method for the repair, regeneration and the replacement of defective tissues [1]. Interconnected 3-dimensional (3D) networks, so called hydrogels, are materials which show promising features for the use as biomaterials in TE [2]. Alginate di-aldehyde (ADA) and gelatin (GEL) are two materials, which are already successfully considered in this field of research [3]. Adding bioactive glasses as inorganic fillers further improves their mechanical as well as biological properties [4]. In addition, the implementation of other bioreactive materials in terms of phytotherapeutics can be used to achieve specific characteristics, such as anti-inflammatory or antibacterial behavior [5]. The aim of this project is to improve the properties of ADA-GEL hydrogels for cell-loaded 3D bioprinting by adding phytotherapeutics loaded mesoporous bioactive glass nano-particles.

 

[1] F. F. Cai, S. Heid, and A. R. Boccaccini, “Potential of Laponite® incorporated oxidized alginate–gelatin (ADA-GEL) composite hydrogels for extrusion-based 3D printing,” J Biomed Mater Res B Appl Biomater, vol. 109, no. 8, pp. 1090–1104, Aug. 2021, doi: 10.1002/jbm.b.34771.

[2] V. Bednarzig, E. Karakaya, A. L. Egaña, J. Teßmar, A. R. Boccaccini, and R. Detsch, “Advanced ADA-GEL bioink for bioprinted artificial cancer models,” Bioprinting, vol. 23, Aug. 2021, doi: 10.1016/j.bprint.2021.e00145.

[3] T. Distler, E. Schaller, P. Steinmann, A. R. Boccaccini, and S. Budday, “Alginate-based hydrogels show the same complex mechanical behavior as brain tissue,” J Mech Behav Biomed Mater, vol. 111, Nov. 2020, doi: 10.1016/j.jmbbm.2020.103979.

[4] F. Bider, E. Karakaya, D. Mohn, Aldo R., and Boccaccini, “Advantages of nanoscale bioactive glass as inorganic filler in alginate hydrogels for drug delivery and biofabrication,” European Journal of Materials, vol. 2, no. 1, pp. 33–53, Dec. 2022, doi: 10.1080/26889277.2022.2039078.

[5] M. A. Akhtar, C. E. Mariotti, B. Conti, and A. R. Boccaccini, “Electrophoretic deposition of ferulic acid loaded bioactive glass/chitosan as antibacterial and bioactive composite coatings,” Surf Coat Technol, vol. 405, Jan. 2021, doi: 10.1016/j.surfcoat.2020.126657.