Javier Guerrero Ancil

Former visiting student (Mondragon University, Spain)

Designing of 3D printed Alginate Di Aldehyde(ADA)-Gelatin(GEL)/ Zinc Doped in Bioactive Glass (ZnBG) scaffolds for Soft Tissue Engineering

 

Supervisor: Dr. Sara Pourshahrestani, Prof. Aldo R. Boccaccini

Due to an increase in the frequency of trauma and pathological disorders, skin wounds have become a serious healthcare issue. Large trauma wounds lead to severe skin loss and are mainly repaired by scarring. Some wounds can even become chronic needing various treatments and making the healing process expensive [1]. 3D printed hydrogels have emerged as a promising tissue engineering and regeneration platform based on their ability to provide an appropriate environment for cell growth. A suitable hydrogel ink formulation is essential to getting a well-defined scaffold with acceptable post-printing shape fidelity. Alginate has seen tremendous interest in this area due to its biocompatibility, biodegradability, simplicity of functionalization, and quick gelling characteristics [2]. In this project the synthesis and characterization of the physiochemical properties of 3D printed alginate dialdehyde-gelatin (ADA-GEL) hydrogel reinforced by the incorporation of zinc doped bioactive glass nanoparticles scaffolds for soft tissue engineering will be investigated. The project expands from previous research carried out at the FAU Institute of Biomaterials on ADA-GEL hydrogels incorporating inorganic nanoparticles (for example [3]).

[1] A. G. Tabriz and D. Douroumis, “Recent advances in 3D printing for wound healing: A systematic review,” J Drug Deliv Sci Technol, vol. 74, p. 103564, Aug. 2022, doi:10.1016/J.JDDST.2022.103564.

[2] S. Pantermehl et al., “3D Printing for Soft Tissue Regeneration and Applications in Medicine,” Biomedicines vol. 9, no. 4, p. 336, Mar. 2021, doi:10.3390/BIOMEDICINES9040336.

[3] M. Monavari, et al., “A 3D Printed Bone Tissue Engineering Scaffold Composed of Alginate Dialdehyde‐Gelatine Reinforced by Lysozyme Loaded Cerium Doped Mesoporous Silica‐Calcia Nanoparticles”, Macromol. Biosc. vol. 22, Sept. 2022, 2200113.