Jiahao Wang

Master student

Synthesis and Characterization of Mesoporous Bioactive Glass Nanoparticles Incorporated Alginate Based Hydrogels for Wound Healing Applications

Supervisors: Prof. Papia Haque, Prof. Aldo R. Boccaccini

Mesoporous bioactive glass nanoparticles (MBGNs) provides a high surface area for improved ion exchange, bioactivity, and protein adsorption in wound healing applications [1]. The composition of different networking and modifying ions of glass structure shows different release kinetics of them which greatly influences the wound healing process. At different stages of the healing, different glass ions promote a particular cell activity. Biomimetic protein incorporated alginate hydrogel as a wound dressing maintains the appropriate mechanical strength and moist environment in the wound area by alginate [2] while the protein promotes cellular adhesion, migration, and proliferation by enabling integrin binding [3]. The present work focuses on the preparation of MBGNs and gelatin added alginate hydrogels to investigate the effects of the glass networking ions of the MBGNs in the tissue generation during wound healing application.

[1] Chen, M. et al. (2024) “Multifunctional bioactive glass nanoparticles: surface-interface decoration and biomedical applications,” Regenerative Biomaterials, 11, p. rbae110. https://doi.org/10.1093/rb/rbae110.

[2] Kong, H.J. et al. (2004) “Controlling rigidity and degradation of alginate hydrogels via molecular weight distribution,” Biomacromolecules, 5(5), pp. 1720–1727. https://doi.org/10.1021/bm049879r.

[3] Bider, F. et al. (2024) “Enhancing alginate dialdehyde-gelatin (ADA-GEL) based hydrogels for biofabrication by addition of phytotherapeutics and mesoporous bioactive glass nanoparticles (MBGNs),” Journal of Biomaterials Applications, https://doi.org/10.1177/08853282241280768.