Lingling Yu

Former masterstudent

Investigation of biphasic scaffolds for osteochondral defect repair

 

Supervisor: Lisa Schoebel, Prof. Aldo R. Boccaccini

The healing response of bone occurs after a fracture. However, if the bone loss exceeds a critical threshold, it is no longer able to perform complete self-repair [1]. In this case, external support by scaffolds is required which can efficiently be manufactured by additive manufacturing [2]. In this project, the aim is to fabricate biphasic scaffolds for osteochondral defect repair using poly(lactic acid)-bioactive glass (PLA-BG) composites [3] as the bone part and alginate di-aldehyde-gelatin (ADA-GEL) hydrogels as the cartilage part. The final scaffolds will be investigated regarding their 3D-printability, chemical and mechanical properties as well as bioactive properties and cell-material interactions

[1] G. Kumar and B. Narayan, “The biology of fracture healing in long bones,” Class. Pap. Orthop., pp. 531–533, 2014.

[2] S. Bose, S. Vahabzadeh, and A. Bandyopadhyay, “Bone tissue engineering using 3D printing,” Mater. Today, vol. 16, no. 12, pp. 496–504, 2013.

[3] T. Distler, et al., “Polymer-Bioactive Glass Composite Filaments for 3D Scaffold Manufacturing by Fused Deposition Modeling: Fabrication and Characterization”, Front. Bioeng. Biotechnol. 8:552, 2020.