Mahshid Monavari

PhD student

2018 – 2020: Visiting researcher (Tehran University of Medical Sciences, Iran)

3D printing of alginate based scaffolds containing bioactive glass particles and phytotherapeutic agents

 

Betreuer: Prof. Dr.-Ing. habil. Aldo R. Boccaccini

The clinical and economic impact of treatments of musculoskeletal injuries is staggering. Tissue engineering (TE) is a promising approach to create custom-made scaffolds that are able to structurally, biologically and mechanically mimic the native tissue that requires repair or replacement while offering a decreased immunological reaction at a low-cost procedure. Based on previous approaches developed at the Erlangen Institute of Biomaterials, ADA-GEL (naturally-derived biopolymer) is a cell-friendly material for scaffold fabrication by 3D printing [1,2].  The addition of plant-derived drugs to tissue engineering scaffolds is gaining increasing attention to enhance the biological performance of scaffolds [3]. The aim of this project is to develop and characterize a new family ADA-GEL composite scaffolds containing bioactive glass particles and phytotherapeutic agents as an osteoinductive system using 3D printing. The biologically activity of the scaffolds in terms of ion release capability (from the bioactive glass particles) and sustained delivery of the phytotherapeutic agents for accelerating bone healing will be investigated.

1.  Sarker B, Singh R, Silva R, Roether JA, Kaschta J, Detsch R, et al. Evaluation of fibroblasts adhesion and proliferation on alginate-gelatin crosslinked hydrogel PLoS One. 9 (2014) e107952.

2. Zehnder T, Sarker B, Boccaccini AR, Detsch R. Evaluation of an alginate-gelatine crosslinked hydrogel for bioplotting. Biofabrication 7 (2015) 025001.

3. Reiter T, Panick T, Schuhladen K, Roether JA, Hum J, Boccaccini AR. Bioactive glass based scaffolds coated with gelatin for the sustained release of icariin Bioact Mater.  4 (2019) 1-7.