Swathi Naidu Vakamulla Raghu

Master Student

Synthesis and analysis of electrospun fiber mats made of natural/synthetic polymers and Boron containing bioactive glass particles as wound dressings

 

Betreuer: Katharina Schuhladen,  Prof. Aldo R. Boccaccini

Wound healing is a complex and dynamic biological process that requires different types of cells to complete the critical steps at the appropriate time [1]. Bioactive glasses are gaining applications in soft tissue repair, including wound healing [2]. In particular, Boron containing bioactive glasses have been shown to promote angiogenesis [3], a key process that promotes the growth of new tissues. In this work we explore wound dressings made of non woven electrospun natural/synthetic polymers and bioactive glass particles containing B. The experiments focus on developing, optimizing, evaluating and comparing polymer solutions containing B doped bioactive glass particles, to successfully fabricate fiber mats that offer structural and functional abilities such as adhesion, moisture retention, porosity/permeability, antibacterial activity and cell activity.

1.    Guo S, and DiPietro LA. Factors Affecting Wound Healing. J Dent Res. 89 (2010) 219–229

2.    Miguez-Pacheco, V., et al., Bioactive glasses beyond bone and teeth: Emerging applications in contact with soft tissues, Acta Biomaterialia 13 (2015) 1-15

3. Balasubramanian, P., et al., Angiogenic potential of boron-containing bioactive glasses: in vitro study, J. Mater. Sci. 52 (2017) 8785–8792