Tobias Leicht

Bachelorstudent

Enhancement of the mechanical performance of PCL/gelatin electrospun scaffolds for tendon regeneration

 

Betreuer: Francesco Iorio, Prof. Aldo R. Boccaccini

The study will focus on the production and characterization of polycaprolactone/gelatin scaffolds, a typical blend employed in tissue
engineering for tendon regeneration /1/, fabricated through the electrospinning technique in a benign solvent system. Combinations of
chemical and physical non-toxic crosslinking methods and the optimal incorporation will be evaluated in the attempt of tailoring the mechanical properties of the scaffolds to the
requirements for tendon regeneration /2/.

[1] Citeroni, M.R et al. Review in vitro innovation of tendon tissue engineering strategies. Int J Mol Sci; 21(18):1-78; 2020.

[2] Sheng, D. et al. Electrospun PCL/Gel-aligned scaffolds enhance the biomechanical strength in tendon repair. J Mater Chem B; 7(31): 4801-10 ; 2019.