Vaijayanthi Ramesh

Former Visiting Researcher (University of Duisburg-Essen)

Reactive Laser Fragmentation and 3D printing of laser-doped Bioglass Nanoparticles

 

Supervisor (UDE): Prof. Dr.-Ing. Stephan Barcikowski

Supervisor (FAU): Prof. Dr.-Ing. habil. Aldo R. Boccaccini

Laser fragmentation in liquids is an established technique to downsize particles to nanometer scales [1]. Using this scalable method, bioactive glass particles can be doped with therapeutic ions in the presence of light-sensitizing ions. Since alginate-based scaffolds are prominently used for their biocompatibility and 3D printing feasibility [2], in this research stay, laser-doped bioactive glass nanoparticles will be incorporated into them and 3D printed. To test the biocompatibility of the printed scaffolds, cultures using MG-63 osteoblast like cells will be performed.

[1] V. Amendola V, et al., Room-temperature laser synthesis in liquid of oxide, metal-oxide core-shells, and doped oxide nanoparticles. Chem. Eur. J. 2020; 26: 9206-9242.

[2] S. Heid et al., Bioprinting with bioactive alginate dialdehyde-gelatin (ADA-GEL) composite bioinks: Time-dependent in-situ crosslinking via addition of calcium-silicate particles tunes in vitro stability of 3D bioprinted constructs, Bioprinting 2022; 26: e00200.