Zeynep Doğa Özdener

Visiting student (Yıldız Technical University, Turkey)

Improvement of antibacterial and antioxidant activity of polycaprolactone films and electrospun fibers by incorporating dual-phytotherapeutic agents for wound healing applications

 

Supervisors: Irem Unalan, Prof. Aldo R. Boccaccini

This project aims to improve the antibacterial and antioxidant activity of polycaprolactone fabricated in film and electrospun fiber forms. In this regard, phytotherapeutic agents are used, which are known for their antibacterial and antioxidant properties, following a technology recently developed in the Erlangen Institute of Biomaterials [1,2]. The fabricated films and electrospun fibers will be investigated regarding their morphology, surface chemistry, wettability, release profile, antioxidant and antibacterial activity.

[1]      I. Unalan, S.J. Endlein, B. Slavik, A. Buettner, W.H. Goldmann, R. Detsch, A.R. Boccaccini, Evaluation of electrospun poly(ε-caprolactone)/gelatin nanofiber mats containing clove essential oil for antibacterial wound dressing, Pharmaceutics. (2019).

[2]      I. Unalan, T. Fuggerer, B. Slavik, A. Buettner, A.R. Boccaccini, Antibacterial and antioxidant activity of cinnamon essential oil-laden 45S5 bioactive glass/soy protein composite scaffolds for the treatment of bone infections and oxidative stress, Mater. Sci. Eng. C. 128 (2021) 112320.