Dr.-Ing. Mirza Mackovic

Aktuell:

Senior researcher / Post Doc

Interaction of proteins with bioreactive surfaces

Betreuer: Prof. Dr.-Ing. habil. Aldo R. Boccaccini

The adsorption of serum proteins on foreign solids leads to the formation of a protein layer (also known as biomolecular corona), which determines the biological identity of the material and is of key importance for the function of its surface [1]. It is well-known that the formed protein layer significantly affects the physicochemical activities (e.g., formation of hydroxyapatite) and controls the biological behaviour (e.g., attachment, proliferation and migration of cells) of biomaterials [2,3]. Hence, the understanding and control of interactions between proteins and biomaterials is of crucial importance for any progress in biomedical applications and/or design of advanced biomedical devices. The current project is focused on the interaction of bioreactive surfaces with proteins. The main work comprises a comprehensive composition- and size-dependent material synthesis and multidisciplinary investigations of protein-surface interactions.

References:

[1] Gray JJ., Curent Opinion in Structural Biology 2004; 14: 110–115.

[2] Wang K, et al., Interface Focus 2012; 2: 259–277.

[3] Wei Q, et al., Angewandte Chemie – International Edition 2014; 53: 8004–8031.

2021

Liebig JP., Mackovic M., Spiecker E., Göken M., Merle B.:
Grain boundary mediated plasticity: A blessing for the ductility of metallic thin films?
In: Acta Materialia 215 (2021), Article No.: 117079
ISSN: 1359-6454
DOI: 10.1016/j.actamat.2021.117079
URL: https://www.sciencedirect.com/science/article/pii/S1359645421004596/pdfft?isDTMRedir=true&download=true

2020

Schrenker N., Xie Z., Schweizer P., Moninger M., Werner F., Karpstein N., Mackovic M., Spyropoulos G., Göbelt M., Christiansen SH., Brabec C., Bitzek E., Spiecker E.:
Microscopic Deformation Modes and Impact of Network Anisotropy on the Mechanical and Electrical Performance of Five-fold Twinned Silver Nanowire Electrodes
In: ACS nano (2020), Article No.: acsnano.0c06480
ISSN: 1936-0851
DOI: 10.1021/acsnano.0c06480

2019

Bei G., Mackovic M., Spiecker E., Greil P.:
Low-temperature oxidation-induced crack healing in Ti2Al0.5Sn0.5C–Al2O3 composites
In: International Journal of Applied Ceramic Technology 16 (2019), p. 1744-1751
ISSN: 1546-542X
DOI: 10.1111/ijac.13315
Schrenker N., Schweizer P., Moninger M., Karpstein N., Mackovic M., Spyropoulos G., Göbelt M., Christiansen S., Brabec C., Spiecker E.:
Mechanical and Electrical Failure of Silver Nanowire Electrodes: A Scale Bridging In Situ Electron Microscopy Study
In: Microscopy and Microanalysis 25 (2019)
ISSN: 1431-9276
DOI: 10.1017/S1431927619010924

2018

So S., Hwang I., Yoo JE., Mohajernia S., Mackovic M., Spiecker E., Cha G., Mazare AV., Schmuki P.:
Inducing a Nanotwinned Grain Structure within the TiO2 Nanotubes Provides Enhanced Electron Transport and DSSC Efficiencies >10%
In: Advanced Energy Materials (2018), Article No.: 1800981
ISSN: 1614-6832
DOI: 10.1002/aenm.201800981

2017

Bochmann S., Fernández-Pacheco A., Mackovic M., Neff A., Siefermann KR., Spiecker E., Cowburn RP., Bachmann J.:
Systematic tuning of segmented magnetic nanowires into three-dimensional arrays of ‘bits’
In: RSC Advances 7 (2017), p. 37627-37635
ISSN: 2046-2069
DOI: 10.1039/c7ra06734h
URL: http://pubs.rsc.org/en/content/articlepdf/2017/RA/C7RA06734H
Distaso M., Zhuromskyy O., Seemann B., Pflug L., Mackovic M., Encina ER., Klupp Taylor R., Müller R., Leugering G., Spiecker E., Peschel U., Peukert W.:
Interaction of light with hematite hierarchical structures: Experiments and simulations
In: Journal of Quantitative Spectroscopy & Radiative Transfer 189 (2017), p. 369-382
ISSN: 0022-4073
DOI: 10.1016/j.jqsrt.2016.12.028
Herre P., Romeis S., Mackovic M., Przybilla T., Paul J., Schwenger J., Torun B., Grundmaier G., Spiecker E., Peukert W.:
Deformation behavior of nanocrystalline titania particles accessed by complementary in situ electron microscopy techniques
In: Journal of the American Ceramic Society (2017), p. 1-14
ISSN: 0002-7820
DOI: 10.1111/jace.15072
URL: http://onlinelibrary.wiley.com/doi/10.1111/jace.15072/epdf
Herre P., Romeis S., Mackovic M., Przybilla T., Paul J., Schwenger J., Torun B., Grundmeier G., Spiecker E., Peukert W.:
Deformation behavior of nanocrystalline titania particles accessed by complementary in situ electron microscopy techniques
In: Journal of the American Ceramic Society 100 (2017), p. 5709-5722
ISSN: 0002-7820
DOI: 10.1111/jace.15072
Kabiri Y., Schrenker N., Müller J., Mackovic M., Spiecker E.:
Direct observation of dislocation formation and plastic anisotropy in Nb2AlC MAX phase using in situ nanomechanics in transmission electron microscopy
In: Scripta Materialia 137 (2017), p. 104-108
ISSN: 1359-6462
DOI: 10.1016/j.scriptamat.2017.04.015
URL: http://www.sciencedirect.com/science/article/pii/S1359646217301914
Mackovic M., Przybilla T., Dieker C., Herre P., Romeis S., Stara H., Schrenker N., Peukert W., Spiecker E.:
A novel approach for preparation and in situ tensile testing of silica glass membranes in the TEM
In: Frontiers in Materials (2017)
ISSN: 2296-8016
DOI: 10.3389/fmats.2017.00010
URL: http://journal.frontiersin.org/article/10.3389/fmats.2017.00010/abstract

2016

Hoffmann B., Bashouti MY., Feichtner T., Mackovic M., Dieker C., Salaheldin AM., Richter P., Gordan OD., Zahn DRT., Spiecker E., Christiansen S., Hoffmann B.:
New insights into colloidal gold flakes: structural investigation, micro-ellipsometry and thinning procedure towards ultrathin monocrystalline layers
In: Nanoscale 8 (2016), p. 4529-4536
ISSN: 2040-3364
DOI: 10.1039/c5nr04439a
Li S., Bei G., Chen X., Zhang L., Zhou Y., Mackovic M., Spiecker E., Greil P.:
Crack healing induced electrical and mechanical properties recovery in a Ti2SnC ceramic
In: Journal of the European Ceramic Society 36 (2016), p. 25-32
ISSN: 0955-2219
DOI: 10.1016/j.jeurceramsoc.2015.09.019
Liebig JP., Göken M., Richter G., Mackovic M., Przybilla T., Spiecker E., Pierron ON., Merle B.:
A flexible method for the preparation of thin film samples for in situ TEM characterization combining shadow-FIB milling and electron beam-assisted etching
In: Ultramicroscopy 171 (2016), p. 82-88
ISSN: 0304-3991
DOI: 10.1016/j.ultramic.2016.09.004
Mackovic M., Niekiel F., Wondraczek L., Bitzek E., Spiecker E.:
In situ mechanical quenching of nanoscale silica spheres in the transmission electron microscope
In: Scripta Materialia 121 (2016), p. 70-74
ISSN: 1359-6462
DOI: 10.1016/j.scriptamat.2016.04.019
URL: http://www.sciencedirect.com/science/article/pii/S1359646216301397

2015

Bashouti MY., Manshina A., Povolotckaia A., Povolotskiy A., Kireev A., Petrov Y., Mackovic M., Spiecker E., Koshevoy I., Tunik S., Christiansen S.:
Direct laser writing of μ-chips based on hybrid C-Au-Ag nanoparticles for express analysis of hazardous and biological substances
In: Lab on A Chip 15 (2015), p. 1742-1747
ISSN: 1473-0197
DOI: 10.1039/C4LC01376J
Bashouti MY., Resch S., Ristein J., Mackovic M., Spiecker E., Waldvogel SR., Christiansen SH.:
Functionalization of Silver Nanowires Surface using Ag-C Bonds in a Sequential Reductive Method
In: ACS Applied Materials and Interfaces 7 (2015), p. 21657-21661
ISSN: 1944-8244
DOI: 10.1021/acsami.5b06830
Frey L., Osvet A., Zhou X., Haeublein V., Schmuki P., Frey L., Spiecker E., Mackovic M., Liu N., Hartmann M., Nakajima T., Venkatesan UM.:
"Black" TiO2 Nanotubes Formed by High-Energy Proton Implantation Show Noble-Metal-co-Catalyst Free Photocatalytic H2-Evolution
In: Nano Letters 15 (2015), p. 6815-6820
ISSN: 1530-6984
DOI: 10.1021/acs.nanolett.5b02663
Paul J., Romeis S., Mackovic M., Marthala V., Herre P., Przybilla T., Hartmann M., Spiecker E., Schmidt J., Peukert W.:
In situ cracking of silica beads in the SEM and TEM - Effect of particle size on structure-property correlations
In: Powder Technology 270 (2015), p. 337--347
ISSN: 0032-5910
DOI: 10.1016/j.powtec.2014.10.026
Wang HQ., Mackovic M., Osvet A., Litzov I., Epelbaum E., Stiegelschmitt A., Batentschuk M., Spiecker E., Brabec C.:
A New Crystal Phase Molybdate Yb2Mo4O15: The Synthesis and Upconversion Properties
In: Particle & Particle Systems Characterization 32 (2015), p. 340-346
ISSN: 0934-0866
DOI: 10.1002/ppsc.201400137

2014

Distaso M., Mackovic M., Spiecker E., Peukert W.:
Formation and Dissolution of Twin ZnO Nanostructures Promoted by Water and Control over Their Emitting Properties
In: Chemistry - A European Journal 20 (2014), p. 8199--8209
ISSN: 0947-6539
DOI: 10.1002/chem.201400100
Klaumünzer M., Distaso M., Hübner J., Mackovic M., Spiecker E., Kryschi C., Peukert W.:
ZnO superstructures via oriented aggregation initiated in a block copolymer melt
In: Crystengcomm 16 (2014), p. 1502-1513
ISSN: 1466-8033
DOI: 10.1039/c3ce41868e
Klaumünzer M., Kahnt A., Burger A., Mackovic M., Muenzel C., Srikantharajah R., Spiecker E., Hirsch A., Peukert W., Guldi DM.:
Surface functionalization and electronic interactions of ZnO nanorods with a porphyrin derivative
In: ACS Applied Materials and Interfaces 6 (2014), p. 6724-6730
ISSN: 1944-8244
DOI: 10.1021/am5004552
Mackovic M., Niekiel F., Wondraczek L., Spiecker E.:
Direct observation of electron-beam-induced densification and hardening of silica nanoballs by in situ transmission electron microscopy and finite element method simulations
In: Acta Materialia 79 (2014), p. 363-373
ISSN: 1359-6454
DOI: 10.1016/j.actamat.2014.05.046

2013

Klaumünzer M., Mackovic M., Ferstl P., Voigt M., Spiecker E., Meyer B., Peukert W.:
Precipitation of In(OH)3 and InOOH nanocrystals for the use in nanoelectronics: Phase transition behavior and oriented aggregation
Nanotechnology 2013: Advanced Materials, CNTs, Particles, Films and Composites - 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013 (Washington, DC)
URL: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84881091856&origin=inward
Klaumünzer M., Münzel C., Burger A., Mackovic M., Voigt M., Spiecker E., Hirsch A., Peukert W.:
An effective dialysis method for surface funtionalization of nanoparticles in liquid phase - Sample: Porphyrine derivatives @ ZnO-Nanorods
Nanotechnology 2013: Advanced Materials, CNTs, Particles, Films and Composites - 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013 (Washington, DC)
URL: https://www.scopus.com/record/display.uri?eid=2-s2.0-84881092806&origin=inward
Klaumünzer M., Weichsel U., Mackovic M., Spiecker E., Peukert W., Kryschi C., Spiecker E., Mackovic M.:
Transmission electron microscopy and time resolved optical spectroscopy study of the electronic and structural interactions of ZnO nanorods with bovine serum albumin
In: Journal of Physical Chemistry B 117 (2013), p. 9683-9689
ISSN: 1520-6106
DOI: 10.1021/jp405181u
Vargas GE., Haro Durand LA., Cadena V., Romero M., Vera Mesones R., Mackovic M., Spallek S., Spiecker E., Boccaccini AR., Gorustovich AA.:
Effect of nano-sized bioactive glass particles on the angiogenic properties of collagen based composites
In: Journal of Materials Science: Materials in Medicine 24 (2013), p. 1261-1269
ISSN: 0957-4530
DOI: 10.1007/s10856-013-4892-7

2012

Distaso M., Mackovic M., Spiecker E., Peukert W.:
Early Stages of Oriented Attachment: Formation of Twin ZnO Nanorods under Microwave Irradiation
In: Chemistry - A European Journal 18 (2012), p. 13265--13268
ISSN: 0947-6539
DOI: 10.1002/chem.201201646
Hanisch M., Mackovic M., Taccardi N., Spiecker E., Klupp Taylor R.:
Synthesis of silver nanoparticle necklaces without explicit addition of reducing or templating agents
In: Chemical Communications 48 (2012), p. 4287-4289
ISSN: 1359-7345
DOI: 10.1039/c2cc30671a
Klaumünzer M., Mackovic M., Ferstl P., Voigt M., Spiecker E., Meyer B., Peukert W.:
Phase Transition Behavior and Oriented Aggregation During Precipitation of In(OH)3 and InOOH Nanocrystals
In: Journal of Physical Chemistry C 116 (2012), p. 24529--24537
ISSN: 1932-7447
DOI: 10.1021/jp305858n
Mackovic M., Hoppe A., Detsch R., Mohn D., Stark WJ., Spiecker E., Boccaccini AR.:
Bioactive glass (type 45S5) nanoparticles: in vitro reactivity on nanoscale and biocompatibility
In: Journal of Nanoparticle Research 14 (2012), p. 966
ISSN: 1388-0764
DOI: 10.1007/s11051-012-0966-6
URL: http://link.springer.com/article/10.1007/s11051-012-0966-6
Yang Y., Lee K., Zobel M., Mackovic M., Unruh T., Spiecker E., Schmuki P.:
Formation of Highly Ordered VO2 Nanotubular/Nanoporous Layers and Their Supercooling Effect in Phase Transitions
In: Advanced Materials 24 (2012), p. 1571-1575
ISSN: 0935-9648
DOI: 10.1002/adma.201200073

2009

Armstrong P., Knieke C., Mackovic M., Frank G., Hartmaier A., Göken M., Peukert W., Mackovic M.:
Microstructural evolution during deformation of tin dioxide nanoparticles in a comminution process
In: Acta Materialia 57 (2009), p. 3060-3071
ISSN: 1359-6454
DOI: 10.1016/j.actamat.2009.02.049