Dr.-Ing. Victoria Wagener

PostDoc am Lehrstuhl Korrosion und Oberflächentechnik – WW4

Bioadaptive coatings on magnesium alloys

Mitarbeiter: Prof. Sanna Virtanen (WW4), Prof. Dr.-Ing. habil. Aldo R. Boccaccini

Mg and Mg-alloys are promising bio-resorbable implant materials due to their outstanding combination of good mechanical properties, biocompatibility and degradability in the human body. The benefit of such materials is huge, as no second operation for the removal of the implant is needed. The main disadvantage for the application of Mg and Mg-alloys in the biomedical field is, however, the excessive corrosion these materials exhibit after implantation, combined with an increase of pH and the formation of hydrogen. Application of coatings is a convenient approach to tackle this problem [1]. The aim of this project is the development of a bio-adaptive coating system on Mg-alloys consisting mainly of a biopolymer and bioactive glass. The formed layers will be investigated concerning their interaction with proteins and cells, their influence on Mg corrosion and their performance in vivo. The project is funded by DFG and it is a collaborative effort with Prof. S. Virtanen (Institute of Surface Science and Corrosion) and Prof. F. Witte (Charité, Berlin)

[1] H. Hornberger, S. Virtanen, A.R. Boccaccini, Biomedical coatings on magnesium alloys – A review, Acta Biomaterialia 8 (2012) 2442-2455.

2016

Wagener V., Schilling A., Mainka A., Hennig D., Gerum R., Kelch ML., Keim S., Fabry B., Virtanen S.:
Cell Adhesion on Surface-Functionalized Magnesium
In: ACS Applied Materials and Interfaces 8 (2016), p. 11998-12006
ISSN: 1944-8244
DOI: 10.1021/acsami.6b01747
Wagener V., Virtanen S.:
Protective Layer Formation on Magnesium in Cell Culture Medium
In: Materials Science and Engineering C 63 (2016), p. 341-351
ISSN: 0928-4931
DOI: 10.1016/j.msec.2016.03.003

2015

Killian M., Seiler S., Wagener V., Hahn R., Ebensperger C., Meyer B., Schmuki P.:
Interface Chemistry and Molecular Bonding of Functional Ethoxysilane-Based Self-Assembled Monolayers on Magnesium Surfaces
In: ACS Applied Materials and Interfaces 7 (2015), p. 9006-9014
ISSN: 1944-8244
DOI: 10.1021/am5075634
Wagener V., Faltz AS., Killian M., Schmuki P., Virtanen S.:
Protein interactions with corroding metal surfaces: Comparison of Mg and Fe
In: Faraday Discussions 180 (2015), p. 347-360
ISSN: 1364-5498
DOI: 10.1039/c4fd00253a

2013

Killian M., Wagener V., Schmuki P.:
Adsorption Characteristics of a Zn-Porphyrin on MgO Surfaces
In: Surface and Interface Analysis 45 (2013), p. 194-197
ISSN: 0142-2421
DOI: 10.1002/sia.4915
Wagener V., Killian M., Turhan CM., Virtanen S.:
Albumin Coating on Magnesium via Linker Molecules – Comparing Different Coating Mechanisms
In: Colloids and Surfaces B-Biointerfaces 103 (2013), p. 586-594
ISSN: 0927-7765
DOI: 10.1016/j.colsurfb.2012.10.060

2010

Killian M., Wagener V., Schmuki P., Virtanen S.:
Functionalization of Metallic Magnesium with Protein Layers via Linker Molecules
In: Langmuir 26 (2010), p. 12044-12048
ISSN: 0743-7463
DOI: 10.1021/la101880r

Dr.-Ing. Victoria Wagener