Francesca E. Ciraldo - Institute of Biomaterials

Francesca E. Ciraldo

Doktorandin

Mesoporous glass coatings with therapeutic ions releasing capability

Betreuer: Prof. Dr.-Ing. habil. Aldo R. Boccaccini

The aim of this research project is the design, processing and characterisation of novel mesoporous glass coatings exhibiting therapeutic ions releasing capability. A controlled amount of specific metallic ions will be introduced during the glass synthesis in order to impart antibacterial effects, in addition to bone formation ability and angiogenesis effects [1, 2]. Electrophoretic deposition [3] will be utilized to develop multifunctional bioactive coating on different substrates (stainless steel, Ti and Mg alloys) for biomedical applications. The novel coatings will be characterised in terms of morphology, chemical composition, strength adhesion to the substrates. Moreover, bioactivity and antibacterial tests will be carried out to verify the bacteriostatic/bactericidal effects imparted by the releasing ions. This research project is being carried out in the framework of the European Training Network (ETN) (Horizon 2020) project: “Advanced glasses, Composites And Ceramics for High growth Industries (CoACH)”.

[1]. Hoppe, A., Mourino, V., Boccaccini, A. R. Therapeutic inorganic ions in bioactive glasses to enhance bone formation and beyond. Biomater. Sci. 1, 254–256 (2013).

2020

Ciraldo F., Arango-Ospina M., Goldmann WH., Beltran AM., Detsch R., Gruenewald A., Roether J., Boccaccini AR.:
Fabrication and characterization of Ag- and Ga-doped mesoporous glass-coated scaffolds based on natural marine sponges with improved mechanical properties
In: Journal of Biomedical Materials Research Part A (2020)
ISSN: 1549-3296
DOI: 10.1002/jbm.a.37123

2019

Ciraldo F.:
Design, processing and characterization of mesoporous glass coatings with therapeutic ion release capability (Dissertation, 2019)
Ciraldo F., Schnepf K., Goldmann W., Boccaccini AR.:
Development and Characterization of Bioactive Glass Containing Composite Coatings with Ion Releasing Function for Antibiotic-Free Antibacterial Surgical Sutures
In: Materials 12 (2019)
ISSN: 1996-1944
DOI: 10.3390/ma12030423
Gritsch L., Maqbool M., Mouriño V., Ciraldo F., Cresswell M., Jackson PR., Lovell C., Boccaccini AR.:
Chitosan/hydroxyapatite composite bone tissue engineering scaffolds with dual and decoupled therapeutic ion delivery: copper and strontium
In: Journal of Materials Chemistry B 7 (2019), p. 6109-6124
ISSN: 2050-750X
DOI: 10.1039/c9tb00897g
Ryan EJ., Ryan AJ., Gonzalez-Vazquez A., Philippart A., Ciraldo F., Hobbs C., Nicolosi V., Boccaccini AR., Kearney CJ., O'Brien FJ.:
Collagen scaffolds functionalised with copper-eluting bioactive glass reduce infection and enhance osteogenesis and angiogenesis both in vitro and in vivo
In: Biomaterials 197 (2019), p. 405-416
ISSN: 0142-9612
DOI: 10.1016/j.biomaterials.2019.01.031
Westhauser F., Senger AS., Obert D., Ciraldo F., Schuhladen K., Schmidmaier G., Moghaddam A., Boccaccini AR.:
Gelatin coating increases in vivo bone formation capacity of three-dimensional 45S5 bioactive glass-based crystalline scaffolds
In: Journal of Tissue Engineering and Regenerative Medicine 13 (2019), p. 179-190
ISSN: 1932-6254
DOI: 10.1002/term.2780

2018

Ciraldo F., Boccardi E., Melli V., Westhauser F., Boccaccini AR.:
Tackling bioactive glass excessive in vitro bioreactivity: Preconditioning approaches for cell culture tests
In: Acta Biomaterialia (2018)
ISSN: 1742-7061
DOI: 10.1016/j.actbio.2018.05.019
Ciraldo F., Liverani L., Gritsch L., Goldmann W., Boccaccini AR.:
Synthesis and characterization of silver-doped mesoporous bioactive glass and its applications in conjunction with electrospinning
In: Materials 11 (2018), Article No.: 692
ISSN: 1996-1944
DOI: 10.3390/ma11050692
Conoscenti G., Pavia FC., Ciraldo F., Liverani L., Brucato V., La Carrubba V., Boccaccini AR.:
In vitro degradation and bioactivity of composite poly-l-lactic (PLLA)/bioactive glass (BG) scaffolds: comparison of 45S5 and 1393BG compositions
In: Journal of Materials Science 53 (2018), p. 2362-2374
ISSN: 0022-2461
DOI: 10.1007/s10853-017-1743-9

2017

Boccardi E., Ciraldo F., Boccaccini AR.:
Bioactive glass-ceramic scaffolds: Processing and properties
In: Mrs Bulletin 42 (2017), p. 226-232
ISSN: 0883-7694
DOI: 10.1557/mrs.2017.28
Hoppe A., Boccardi E., Ciraldo F., Boccaccini AR., Hill RG.:
Bioactive Glass-Ceramics
In: Comprehensive Biomaterials II, Elsevier, 2017, p. 235-243 (Reference Module in Materials Science and Materials Engineering, Vol.1)
ISBN: 9780081006924
DOI: 10.1016/B978-0-12-803581-8.10238-3
Westhauser F., Ciraldo F., Balasubramanian P., Senger AS., Schmidmaier G., Moghaddam A., Boccaccini AR.:
Micro-computed-tomography-guided analysis of in vitro structural modifications in two types of 45S5 bioactive glass based scaffolds
In: Materials 10 (2017), Article No.: 1341
ISSN: 1996-1944
DOI: 10.3390/ma10121341

2015

Miola M., Verne E., Ciraldo F., Cordero Arias LE., Boccaccini AR.:
Electrophoretic Deposition of Chitosan/45S5 Bioactive Glass Composite Coatings Doped with Zn and Sr
In: Frontiers in Bioengineering and Biotechnology 3 (2015), Article No.: 159
ISSN: 2296-4185
DOI: 10.3389/fbioe.2015.00159