Dr.-Ing. Preethi Balasubramanian - Institute of Biomaterials

Dr.-Ing. Preethi Balasubramanian

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Post Doc

Mesoporous bioactive glass particles for localized release of therapeutic ions and drugs

Betreuer: Prof. Dr. –Ing. habil. Aldo R. Boccaccini

This research project involves the synthesis of mesoporous bioactive glass nanoparticles as smart platforms for effective, non-invasive and highly targeted therapies to treat delayed bone healing and non-healing chronic skin wounds. For this purpose, mesoporous glasses are doped with specific ions which play additional roles in osteogenesis, angiogenesis and antibacterial applications [1]. Surface morphology, pore size distribution, bioactivity and in vitro cytocompatibility of the synthesized inorganic nanomatrices will be characterized. The project is being carried out in the framework of the EU funded project “MesopOrous matrices for localiZed pH-triggered releAse of theRapeuTic ions and drugs (MOZART)”

[1] A. Hoppe, V. Mouriño, and A.R. Boccaccini, “Therapeutic inorganic ions in bioactive glasses to enhance bone formation and beyond,” Biomater. Sci., 1 [3] 254–256 (2013).

Zeitraum: 2013 – 2016 (Dokrorand)

Thema / Repräsentative Veröffentlichung:

Surface modification of bioactive glass scaffolds

P. Balasubramanian, L. Hupa, B. Jokic, R. Detsch, A. Grünewald, and A.R. Boccaccini, “Angiogenic potential of boron-containing bioactive glasses: in vitro study,” J. Mater. Sci., in press (2017)

weitere Informationen: Zur Zeit: PostDoc am Lehrstuhl Biomaterialien, Universität Erlangen-Nürnberg

2020

Zheng K., Fan Y., Torre E., Balasubramanian P., Taccardi N., Cassinelli C., Morra M., Iviglia G., Boccaccini AR.:
Incorporation of Boron in Mesoporous Bioactive Glass Nanoparticles Reduces Inflammatory Response and Delays Osteogenic Differentiation
In: Particle & Particle Systems Characterization (2020)
ISSN: 0934-0866
DOI: 10.1002/ppsc.202000054

2019

Bellucci D., Braccini S., Chiellini F., Balasubramanian P., Boccaccini AR., Cannillo V.:
Bioactive glasses and glass-ceramics versus hydroxyapatite: Comparison of angiogenic potential and biological responsiveness
In: Journal of Biomedical Materials Research Part A (2019)
ISSN: 1549-3296
DOI: 10.1002/jbm.a.36766
Zheng K., Balasubramanian P., Paterson TE., Stein R., MacNeil S., Fiorilli S., Vitale-Brovarone C., Shepherd J., Boccaccini AR.:
Ag modified mesoporous bioactive glass nanoparticles for enhanced antibacterial activity in 3D infected skin model
In: Materials Science and Engineering C 103 (2019), Article No.: 109764
ISSN: 0928-4931
DOI: 10.1016/j.msec.2019.109764

2018

Balasubramanian P., Büttner T., Miguez Pacheco V., Boccaccini AR.:
Boron-containing bioactive glasses in bone and soft tissue engineering
In: Journal of the European Ceramic Society 38 (2018), p. 855-869
ISSN: 0955-2219
DOI: 10.1016/j.jeurceramsoc.2017.11.001
Balasubramanian P., Salinas AJ., Sanchez-Salcedo S., Detsch R., Vallet-Regi M., Boccaccini AR.:
Induction of VEGF secretion from bone marrow stromal cell line (ST-2) by the dissolution products of mesoporous silica glass particles containing CuO and SrO
In: Journal of Non-Crystalline Solids 500 (2018), p. 217-224
ISSN: 0022-3093
DOI: 10.1016/j.jnoncrysol.2018.07.073
El-Rashidy AA., Waly G., Gad A., Hashem AA., Balasubramanian P., Kaya S., Boccaccini AR., Sami I.:
Preparation and in vitro characterization of silver-doped bioactive glass nanoparticles fabricated using a sol-gel process and modified Stöber method
In: Journal of Non-Crystalline Solids 483 (2018), p. 26-36
ISSN: 0022-3093
DOI: 10.1016/j.jnoncrysol.2017.12.044

2017

Balasubramanian P., Detsch R., Esteban-Tejeda L., Grünewald A., Moya JS., Boccaccini AR.:
Influence of dissolution products of a novel Ca-enriched silicate bioactive glass-ceramic on VEGF release from bone marrow stromal cells
In: Biomedical Glasses 3 (2017), p. 104-110
ISSN: 2299-3932
DOI: 10.1515/bglass-2017-0010
Balasubramanian P., Hupa L., Jokic B., Detsch R., Grünewald A., Boccaccini AR.:
Angiogenic potential of boron-containing bioactive glasses: in vitro study
In: Journal of Materials Science 52 (2017), p. 8785-8792
ISSN: 0022-2461
DOI: 10.1007/s10853-016-0563-7
Sengottuvelan A., Balasubramanian P., Will J., Boccaccini AR.:
Bioactivation of titanium dioxide scaffolds by ALP-functionalization
In: Bioactive Materials 2 (2017), p. 108-115
ISSN: 2452-199X
DOI: 10.1016/j.bioactmat.2017.02.004
Westhauser F., Ciraldo F., Balasubramanian P., Senger AS., Schmidmaier G., Moghaddam A., Boccaccini AR.:
Micro-computed-tomography-guided analysis of in vitro structural modifications in two types of 45S5 bioactive glass based scaffolds
In: Materials 10 (2017), Article No.: 1341
ISSN: 1996-1944
DOI: 10.3390/ma10121341

2016

Balasubramanian P.:
Oberflächenmodifikation von bioaktiven Glasstützstrukturen (Thesis, 2016)
URL: https://nbn-resolving.org/urn:nbn:de:bvb:29-opus4-85662
Balasubramanian P., Grünewald A., Detsch R., Hupa L., Jokic B., Tallia F., Solanki AK., Jones JR., Boccaccini AR.:
Ion Release, Hydroxyapatite Conversion, and Cytotoxicity of Boron-Containing Bioactive Glass Scaffolds
In: International Journal of Applied Glass Science 7 (2016), p. 206-215
ISSN: 2041-1286
DOI: 10.1111/ijag.12206
Goudouri OM., Balasubramanian P., Boccaccini AR.:
Characterizing the degradation behavior of bioceramic scaffolds
Elsevier Inc., 2016
ISBN: 9781782420958
DOI: 10.1016/B978-1-78242-087-3.00006-7

2015

Balasubramanian P., Boccaccini AR.:
Bilayered bioactive glass scaffolds incorporating fibrous morphology by flock technology
In: Materials Letters 158 (2015), p. 313-316
ISSN: 0167-577X
DOI: 10.1016/j.matlet.2015.06.036
Balasubramanian P., Roether J., Schubert DW., Beier J., Boccaccini AR.:
Bi-layered porous constructs of PCL-coated 45S5 bioactive glass and electrospun collagen-PCL fibers
In: Journal of Porous Materials 22 (2015), p. 1215-1226
ISSN: 1380-2224
DOI: 10.1007/s10934-015-9998-5
Balasubramanian P., Strobel L., Kneser U., Boccaccini AR.:
Zinc-containing bioactive glasses for bone regeneration, dental and orthopedic applications
In: Biomedical Glasses 1 (2015), p. 51-69
ISSN: 2299-3932
DOI: 10.1515/bglass-2015-0006