Dr.-Ing. Kai Zheng
Dr.-Ing. Kai Zheng
2017 – 2021: Post Doc
Processing, characterisation and applications of multifunctional mesoporous bioactive glass nanoparticles
Supervisor: Prof. Dr.-Ing. habil. Aldo R. Boccaccini
My main research project involves the development of smart platforms for effective, non-invasive, and highly targeted therapies to treat delayed bone healing and non-healing chronic skin wounds. For this purpose, solid and hollow mesoporous bioactive glass nanoparticles (MBGN) are being developed for controlled delivery of therapeutic agents [1]. Specific bioactive ions that can promote osteogenesis, angiogenesis and with antibacterial potential are bein considered to dope these MBGN to enhance bone regeneration or wound healing [2]. The project is being carried out in the framework of the EU funded project (“MOZART”) “MesopOrous matrices for localiZed pH-triggered releAse of theRapeuTic ions and drugs” (LINK: http://www.mozartproject.eu/).
[1] K. Zheng, A.R. Boccaccini, Sol-gel processing of bioactive glass nanoparticles: A review, Adv. Colloid Interface Sci. (2017) In Press.
[2] A. Hoppe, N.S. Güldal, A.R. Boccaccini, A review of the biological response to ionic dissolution products from bioactive glasses and glass-ceramics., Biomaterials. 32 (2011) 2757–2774.
Zeitraum: 2013 – 2017
Thema / Repräsentative Veröffentlichung:
Bioactive glass scaffolds incorporating ion release function for enhaced bone formation
K. Zheng, et al., Timing of calcium nitrate addition affects morphology, dispersity and composition of bioactive glass nanoparticles, RSC Advances 6 (2016) 95101-95111.
weitere Informationen: Zur Zeit: PostDoc am Lehrstuhl Biomaterialien, Universität Erlangen-Nürnberg
2024
pH-Triggered Controlled Release of Chlorhexidine Using Chitosan-Coated Titanium Silica Composite for Dental Infection Prevention
In: Pharmaceutics 16 (2024), Article No.: 377
ISSN: 1999-4923
DOI: 10.3390/pharmaceutics16030377 , , , , , , , , , :
2023
Composite materials of amorphous calcium phosphate and bioactive glass nanoparticles for preventive dentistry
In: Ceramics International (2023)
ISSN: 0272-8842
DOI: 10.1016/j.ceramint.2023.10.137 , , , , , , :
2022
Copper-doped cotton-like malleable electrospun bioactive glass fibers for wound healing applications
In: Materials Letters: X 14 (2022), Article No.: 100133
ISSN: 2590-1508
DOI: 10.1016/j.mlblux.2022.100133 , , , , :
Synthesis and characterization of a collagen-based composite material containing selenium nanoparticles
In: Journal of Biomaterials Applications (2022)
ISSN: 0885-3282
DOI: 10.1177/08853282211073731 , , , , , , , , :
A Self-Assembled Matrix System for Cell-Bioengineering Applications in Different Dimensions, Scales, and Geometries
In: Small (2022)
ISSN: 1613-6829
DOI: 10.1002/smll.202104758 , , , , , , , , , , , , , , , :
3D Bioprinting of Multifunctional Dynamic Nanocomposite Bioinks Incorporating Cu-Doped Mesoporous Bioactive Glass Nanoparticles for Bone Tissue Engineering
In: Small (2022)
ISSN: 1613-6829
DOI: 10.1002/smll.202104996 , , , , , , , , , :
2021
A shelf-life study of silica- and carbon-based mesoporous materials
In: Journal of Industrial and Engineering Chemistry 101 (2021), p. 205-213
ISSN: 1226-086X
DOI: 10.1016/j.jiec.2021.06.011 , , , , , , , , , , , , , , , , , :
Fabrication and characterization of cinnamaldehyde-loaded mesoporous bioactive glass nanoparticles/phbv-based microspheres for preventing bacterial infection and promoting bone tissue regeneration
In: Polymers 13 (2021), Article No.: 1794
ISSN: 2073-4360
DOI: 10.3390/polym13111794 , , , , , :
Comparative Study of the Antimicrobial Activity of Selenium Nanoparticles With Different Surface Chemistry and Structure
In: Frontiers in Bioengineering and Biotechnology 8 (2021), Article No.: 624621
ISSN: 2296-4185
DOI: 10.3389/fbioe.2020.624621 , , , , , , :
Protein adsorption on sio2-cao bioactive glass nanoparticles with controllable ca content
In: Nanomaterials 11 (2021), p. 1-13
ISSN: 2079-4991
DOI: 10.3390/nano11030561 , , , , :
Artificial extracellular matrices containing bioactive glass nanoparticles promote osteogenic differentiation in human mesenchymal stem cells
In: International Journal of Molecular Sciences 22 (2021), Article No.: 12819
ISSN: 1422-0067
DOI: 10.3390/ijms222312819 , , , , , , , , , , , , , :
Cerium and gallium containing mesoporous bioactive glass nanoparticles for bone regeneration: Bioactivity, biocompatibility and antibacterial activity
In: Materials Science and Engineering C 124 (2021), Article No.: 112050
ISSN: 0928-4931
DOI: 10.1016/j.msec.2021.112050 , , , , , , , , :
Editorial: Hybrids Part B: Hybrids for Drug Delivery
In: Frontiers in Bioengineering and Biotechnology 9 (2021)
ISSN: 2296-4185
DOI: 10.3389/fbioe.2021.720714 , , :
Incorporation of copper-doped mesoporous bioactive glass nanospheres in experimental dental composites: Chemical and mechanical characterization
In: Materials 14 (2021), Article No.: 2611
ISSN: 1996-1944
DOI: 10.3390/ma14102611 , , , , , , :
Combination of selective etching and impregnation toward hollow mesoporous bioactive glass nanoparticles
In: Nanomaterials 11 (2021), Article No.: 1846
ISSN: 2079-4991
DOI: 10.3390/nano11071846 , , , , , :
Development of alginate dialdehyde-gelatin based bioink with methylcellulose for improving printability
In: Materials Science and Engineering C 128 (2021), Article No.: 112336
ISSN: 0928-4931
DOI: 10.1016/j.msec.2021.112336 , , , , , :
Cerium oxide nanoparticles loaded nanofibrous membranes promote bone regeneration for periodontal tissue engineering
In: Bioactive Materials (2021)
ISSN: 2452-199X
DOI: 10.1016/j.bioactmat.2021.05.037 , , , , , , , , :
Ionic dissolution products of Cerium-doped bioactive glass nanoparticles promote cellular osteogenic differentiation and extracellular matrix formation of human bone marrow derived mesenchymal stromal cells
In: Biomedical Materials 16 (2021), Article No.: 035028
ISSN: 1748-6041
DOI: 10.1088/1748-605X/abcf5f , , , , , , :
Bioactive Glass Flakes as Innovative Fillers in Chitosan Membranes for Guided Bone Regeneration
In: Advanced Engineering Materials (2021), Article No.: 2101042
ISSN: 1438-1656
DOI: 10.1002/adem.202101042 , , , , , , , :
Immunomodulatory bioactive glasses for tissue regeneration
In: Acta Biomaterialia (2021)
ISSN: 1742-7061
DOI: 10.1016/j.actbio.2021.08.023 , , , :
Hybrids Part A: Hybrids for Tissue Regeneration
In: Frontiers in Bioengineering and Biotechnology 9 (2021), Article No.: 746641
ISSN: 2296-4185
DOI: 10.3389/fbioe.2021.746641 , , :
Porous bioactive glass micro- And nanospheres with controlled morphology: Developments, properties and emerging biomedical applications
In: Materials Horizons 8 (2021), p. 300-335
ISSN: 2051-6347
DOI: 10.1039/d0mh01498b , , , :
Hybrid gelatin/oxidized chondroitin sulfate hydrogels incorporating bioactive glass nanoparticles with enhanced mechanical properties, mineralization, and osteogenic differentiation
In: Bioactive Materials 6 (2021), p. 890-904
ISSN: 2452-199X
DOI: 10.1016/j.bioactmat.2020.09.012 , , , , , , , , , , , , , :
Multi-functional silica-based mesoporous materials for simultaneous delivery of biologically active ions and therapeutic biomolecules
In: Acta Biomaterialia 129 (2021), p. 1-17
ISSN: 1742-7061
DOI: 10.1016/j.actbio.2021.05.007 , , :
2020
In Vivo Validation of Spray-Dried Mesoporous Bioactive Glass Microspheres Acting as Prolonged Local Release Systems for BMP-2 to Support Bone Regeneration
In: Pharmaceutics 12 (2020)
ISSN: 1999-4923
DOI: 10.3390/pharmaceutics12090823 , , , , , , , , , , :
Electrospun PCL fiber mats incorporating multi-targeted B and Co Co-doped bioactive glass nanoparticles for angiogenesis
In: Materials 13 (2020), Article No.: 4010
ISSN: 1996-1944
DOI: 10.3390/ma13184010 , , , , , , , :
Multi-targeted B and Co co-doped 45S5 bioactive glasses with angiogenic potential for bone regeneration
In: Materials Science and Engineering C 112 (2020), Article No.: 110909
ISSN: 0928-4931
DOI: 10.1016/j.msec.2020.110909 , , , , , , , , , , , :
Effects of Medium pH and Preconditioning Treatment on Protein Adsorption on 45S5 Bioactive Glass Surfaces
In: Advanced Materials Interfaces (2020)
ISSN: 2196-7350
DOI: 10.1002/admi.202000420 , , , , , , , :
Sponge-derived natural bioactive glass microspheres with self-assembled surface channel arrays opening into a hollow core for bone tissue and controlled drug release applications
In: Chemical Engineering Journal (2020), Article No.: 126667
ISSN: 1385-8947
DOI: 10.1016/j.cej.2020.126667 , , , , , , , , , , , , , :
Synthesis and characterization of rubidium-containing bioactive glass nanoparticles
In: Materials Letters 273 (2020), Article No.: 127920
ISSN: 0167-577X
DOI: 10.1016/j.matlet.2020.127920 , , , , :
Microscale electric fields induced by galvanically coupled Ti-Mg metal-metal composites promote antibacterial activity
In: Materialia 9 (2020), Article No.: 100621
ISSN: 2589-1529
DOI: 10.1016/j.mtla.2020.100621 , , , , :
Biocompatible, Flexible Strain Sensor Fabricated with Polydopamine-Coated Nanocomposites of Nitrile Rubber and Carbon Black
In: ACS Applied Materials and Interfaces 12 (2020), p. 42140-42152
ISSN: 1944-8244
DOI: 10.1021/acsami.0c11937 , , , , , , , :
Biofabrication and Characterization of Alginate Dialdehyde-Gelatin Microcapsules Incorporating Bioactive Glass for Cell Delivery Application
In: Macromolecular Bioscience (2020)
ISSN: 1616-5187
DOI: 10.1002/mabi.202000138 , , , , :
Enhanced bacteriostatic activity, osteogenesis and osseointegration of silicon nitride/polyetherketoneketone composites with femtosecond laser induced micro/nano structural surface
In: Applied Materials Today 18 (2020), Article No.: 100523
ISSN: 2352-9407
DOI: 10.1016/j.apmt.2019.100523 , , , , , , , , , , :
Incorporation of Boron in Mesoporous Bioactive Glass Nanoparticles Reduces Inflammatory Response and Delays Osteogenic Differentiation
In: Particle & Particle Systems Characterization (2020)
ISSN: 0934-0866
DOI: 10.1002/ppsc.202000054 , , , , , , , , :
Antioxidant mesoporous Ce-doped bioactive glass nanoparticles with anti-inflammatory and pro-osteogenic activities
In: Materials Today Bio 5 (2020), Article No.: 100041
ISSN: 2590-0064
DOI: 10.1016/j.mtbio.2020.100041 , , , , , , , , , :
In vitro evaluation of poly (vinyl alcohol)/collagen blended hydrogels for regulating human periodontal ligament fibroblasts and gingival fibroblasts
In: International Journal of Biological Macromolecules 163 (2020), p. 1938-1946
ISSN: 0141-8130
DOI: 10.1016/j.ijbiomac.2020.09.033 , , , , :
Engineering microstructure of hydroxyapatite by electron beam irradiation to induce controllable in vitro degradation
In: Applied Surface Science 528 (2020), Article No.: 146583
ISSN: 0169-4332
DOI: 10.1016/j.apsusc.2020.146583 , , , , , :
2019
Mechanical improvement of calcium carbonate cements by: In situ HEMA polymerization during hardening
In: Journal of Materials Chemistry B 7 (2019), p. 3403-3411
ISSN: 2050-750X
DOI: 10.1039/c9tb00237e , , , , :
Multifunctional zinc ion doped sol – gel derived mesoporous bioactive glass nanoparticles for biomedical applications
In: Bioactive Materials 4 (2019), p. 312-321
ISSN: 2452-199X
DOI: 10.1016/j.bioactmat.2019.10.002 , , , , , , , , :
Thermally triggered injectable chitosan/silk fibroin/bioactive glass nanoparticle hydrogels for in-situ bone formation in rat calvarial bone defects
In: Acta Biomaterialia (2019)
ISSN: 1742-7061
DOI: 10.1016/j.actbio.2019.04.023 , , , , , , , , :
Ag modified mesoporous bioactive glass nanoparticles for enhanced antibacterial activity in 3D infected skin model
In: Materials Science and Engineering C 103 (2019), Article No.: 109764
ISSN: 0928-4931
DOI: 10.1016/j.msec.2019.109764 , , , , , , , , :
Toward Highly Dispersed Mesoporous Bioactive Glass Nanoparticles With High Cu Concentration Using Cu/Ascorbic Acid Complex as Precursor
In: Frontiers in Chemistry 7 (2019)
ISSN: 2296-2646
DOI: 10.3389/fchem.2019.00497 , , , , , , , , , :
Protein interactions with bioactive glass surfaces: A review
In: Applied Materials Today 15 (2019), p. 350-371
ISSN: 2352-9407
DOI: 10.1016/j.apmt.2019.02.003 , , :
2018
Electrospun Polyhydroxybutyrate/Poly(ε-caprolactone)/Sol-Gel-Derived Silica Hybrid Scaffolds with Drug Releasing Function for Bone Tissue Engineering Applications.
In: ACS Applied Materials and Interfaces 10 (2018), p. 14540-14548
ISSN: 1944-8244
DOI: 10.1021/acsami.8b02656 , , , , , , , , , :
Electrospun Polyhydroxybutyrate/Poly(ϵ-caprolactone)/Sol-Gel-Derived Silica Hybrid Scaffolds with Drug Releasing Function for Bone Tissue Engineering Applications
In: ACS Applied Materials and Interfaces 10 (2018), p. 14540-14548
ISSN: 1944-8244
DOI: 10.1021/acsami.8b02656
URL: https://www.ncbi.nlm.nih.gov/pubmed/29624366 , , , , , , , , , :
Bioactive Carbon-Based Hybrid 3D Scaffolds for Osteoblast Growth
In: ACS Applied Materials and Interfaces 10 (2018), p. 43874-43886
ISSN: 1944-8244
DOI: 10.1021/acsami.8b13631 , , , , , , :
Highly dispersed lithium doped mesoporous silica nanospheres regulating adhesion, proliferation, morphology, ALP activity and osteogenesis related gene expressions of BMSCs.
In: Colloids and Surfaces B-Biointerfaces 170 (2018), p. 563-571
ISSN: 0927-7765
DOI: 10.1016/j.colsurfb.2018.06.038 , , , , , , , , , :
Incorporation of Cu-Containing Bioactive Glass Nanoparticles in Gelatin-Coated Scaffolds Enhances Bioactivity and Osteogenic Activity
In: ACS Biomaterials Science and Engineering 4 (2018), p. 1546-1557
ISSN: 2373-9878
DOI: 10.1021/acsbiomaterials.8b00051 , , , , , :
2017
Macro-mesoporous composites containing PEEK and mesoporous diopside as bone implants: Characterization, in vitro mineralization, cytocompatibility, and vascularization potential and osteogenesis in vivo
In: Journal of Materials Chemistry B 5 (2017), p. 8337-8352
ISSN: 2050-750X
DOI: 10.1039/c7tb02344h , , , , , , , , , :
Cu-releasing bioactive glass/polycaprolactone coating on Mg with antibacterial and anticorrosive properties for bone tissue engineering
In: Biomedical Materials 13 (2017), Article No.: 015001
ISSN: 1748-6041
DOI: 10.1088/1748-605X/aa87f2 , , , , , , , , , :
Synthese und Modifizierung von bioaktiven Glasnanopartikeln für biomedizinische Anwendungen (Thesis, 2017)
URL: https://nbn-resolving.org/urn:nbn:de:bvb:29-opus4-86519 :
Sol-gel processing of bioactive glass nanoparticles: A review
In: Advances in Colloid and Interface Science 249 (2017), p. 363-373
ISSN: 0001-8686
DOI: 10.1016/j.cis.2017.03.008 , :
Synthesis of copper-containing bioactive glass nanoparticles using a modified Stöber method for biomedical applications
In: Colloids and Surfaces B-Biointerfaces 150 (2017), p. 159-167
ISSN: 0927-7765
DOI: 10.1016/j.colsurfb.2016.11.016 , , , , , :
2016
Bone tissue scaffolds based on antimicrobial SiO2-Na2O-Al2O3-CaO-B2O3 glass
In: Journal of Non-Crystalline Solids 432 (2016), p. 73-80
ISSN: 0022-3093
DOI: 10.1016/j.jnoncrysol.2015.05.040 , , , , , , :
Influences of mesoporous magnesium silicate on the hydrophilicity, degradability, mineralization and primary cell response to a wheat protein based biocomposite
In: Journal of Materials Chemistry B 4 (2016), p. 6428-6436
ISSN: 2050-750X
DOI: 10.1039/c6tb01449f , , , , , , , , , :
Synthesis of monodispersed Ag-doped bioactive glass nanoparticles via surface modification
In: Materials 9 (2016), Article No.: 225
ISSN: 1996-1944
DOI: 10.3390/ma9040225 , , , , , :
Designing Porous Bone Tissue Engineering Scaffolds with Enhanced Mechanical Properties from Composite Hydrogels Composed of Modified Alginate, Gelatin, and Bioactive Glass
In: ACS Biomaterials Science and Engineering 2 (2016), p. 2240-2254
ISSN: 2373-9878
DOI: 10.1021/acsbiomaterials.6b00470 , , , , :
Effects of magnesium silicate on the mechanical properties, biocompatibility, bioactivity, degradability, and osteogenesis of poly(butylene succinate)-based composite scaffolds for bone repair
In: Journal of Materials Chemistry B 4 (2016), p. 7974-7988
ISSN: 2050-750X
DOI: 10.1039/c6tb02429g , , , , , , :
Monodispersed lysozyme-functionalized bioactive glass nanoparticles with antibacterial and anticancer activities
In: Biomedical Materials 11 (2016), Article No.: 035012
ISSN: 1748-6041
DOI: 10.1088/1748-6041/11/3/035012 , , , , , , :
ZnO quantum dots modified bioactive glass nanoparticles with pH-sensitive release of Zn ions, fluorescence, antibacterial and osteogenic properties
In: Journal of Materials Chemistry B 4 (2016), p. 7936-7949
ISSN: 2050-750X
DOI: 10.1039/C6TB02053D , , , , , , , , , :
Timing of calcium nitrate addition affects morphology, dispersity and composition of bioactive glass nanoparticles
In: RSC Advances 6 (2016), p. 95101-95111
ISSN: 2046-2069
DOI: 10.1039/c6ra05548f , , , , , , , :
2015
Aging Time and Temperature Effects on the Structure and Bioactivity of Gel-Derived 45S5 Glass-Ceramics
In: Journal of the American Ceramic Society 98 (2015), p. 30-38
ISSN: 0002-7820
DOI: 10.1111/jace.13258 , , , , , , :
Preparation and characterization of fibrous chitosan-glued phosphate glass fiber scaffolds for bone regeneration
In: Journal of Materials Science: Materials in Medicine 26 (2015), Article No.: 224
ISSN: 0957-4530
DOI: 10.1007/s10856-015-5554-8 , , , , , :
2014
Ultrasonic elasticity determination of 45S5 Bioglass®-based scaffolds: Influence of polymer coating and crosslinking treatment
In: Journal of the Mechanical Behavior of Biomedical Materials 40 (2014), p. 85-94
ISSN: 1878-0180
DOI: 10.1016/j.jmbbm.2014.08.010 , , , , , :
Bio-templated bioactive glass particles with hierarchical macro-nano porous structure and drug delivery capability
In: Colloids and Surfaces B: Biointerfaces 135 (2014), p. 825-832
ISSN: 0927-7765
DOI: 10.1016/j.colsurfb.2015.03.038 , , , , , , , :
2013
Nanoscale Bioactive Glasses in Medical Applications
In: International Journal of Applied Glass Science 4 (2013), p. 136-148
ISSN: 2041-1286
DOI: 10.1111/ijag.12029 , , :